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Nimrat Chatterjee

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Nimrat Chatterjee
OccupationMolecular biologist, academic
EducationPh.D., Biochemistry and Molecular Biology
Alma materBaylor College of Medicine

Nimrat Chatterjee is a molecular biologist and Assistant Professor in the Department of Microbiology and Molecular Genetics at the University of Vermont.[1] Her work focuses on translesion synthesis and DNA damage mutagenesis, including the identification of small molecule inhibitors of the Rev1-Polζ complex as a strategy to improve chemotherapy outcomes.[2]

Education

Chatterjee received a Ph.D. in Biochemistry and Molecular Biology from Baylor College of Medicine in 2014.[3]

Career

From 2016 to 2020, Chatterjee was a Postdoctoral Associate in the Department of Biology at the Massachusetts Institute of Technology.[4] In 2020, she joined the University of Vermont as an Assistant Professor in the Department of Microbiology and Molecular Genetics.[5]

Research

Chatterjee's research addresses mechanisms of DNA damage, repair, and mutagenesis, with a particular emphasis on translesion synthesis. According to Semantic Scholar, her publication record comprises 36 papers with a total of 2,218 citations and an h-index of 12.[6]

Her studies have examined small molecule inhibitors targeting the Rev1-CT/RIR protein-protein interaction as a means of disrupting translesion synthesis and enhancing chemotherapy efficacy, as well as the dimerization of Rev7 in the assembly of the Rev1/Polζ complex.[7] She has also investigated environmental stress as a driver of trinucleotide repeat mutagenesis in human cells and the DNA damage response triggered by SARS-CoV-2 infection.[8]

Chatterjee has been supported by National Institutes of Health funding through a project titled "Mechanistic insights into translesion synthesis-dependent genome instability," administered through the University of Vermont and State Agricultural College, totaling $1,543,254 across award periods.[9]

Selected publications

  • "Mechanisms of DNA damage, repair and mutagenesis," Environmental and Molecular Mutagenesis (2017)[10]
  • "A small molecule targeting mutagenic translesion synthesis improves chemotherapy," Cell (2019)[11]
  • "Inhibition of mutagenic translesion synthesis: A possible strategy for improving chemotherapy?" PLoS Genetics (2017)[12]
  • "Rev7 dimerization is important for assembly and function of the Rev1/Polζ translesion synthesis complex," Proceedings of the National Academy of Sciences of the United States of America (2018)[13]
  • "Identification of small molecule translesion synthesis inhibitors that target the Rev1-CT/RIR protein-protein interaction," ACS Chemical Biology (2017)[14]
  • "Environmental stress induces trinucleotide repeat mutagenesis in human cells," Proceedings of the National Academy of Sciences of the United States of America (2015)[15]
  • "SARS-CoV-2 triggers DNA damage response in Vero E6 cells," bioRxiv (2021)[16]
  • "REV1 inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks," Proceedings of the National Academy of Sciences of the United States of America (2020)[17]
  • "REV1 Inhibition Enhances Radioresistance and Autophagy," Cancers (2021)[18]
  • "Virtual Pharmacophore Screening Identifies Small Molecule Inhibitors of the Rev1-CT/RIR Protein-Protein Interaction," ChemMedChem (2019)[19]
  1. ↑ University of Vermont faculty directory
  2. ↑ Semantic Scholar publication record for Nimrat Chatterjee
  3. ↑ ORCID record 0000-0001-6556-9423
  4. ↑ ORCID record 0000-0001-6556-9423
  5. ↑ ORCID record 0000-0001-6556-9423
  6. ↑ Semantic Scholar publication record for Nimrat Chatterjee
  7. ↑ Semantic Scholar publication record for Nimrat Chatterjee
  8. ↑ Semantic Scholar publication record for Nimrat Chatterjee
  9. ↑ NIH RePORTER grant records
  10. ↑ Semantic Scholar publication record for Nimrat Chatterjee
  11. ↑ Semantic Scholar publication record for Nimrat Chatterjee
  12. ↑ Semantic Scholar publication record for Nimrat Chatterjee
  13. ↑ Semantic Scholar publication record for Nimrat Chatterjee
  14. ↑ Semantic Scholar publication record for Nimrat Chatterjee
  15. ↑ Semantic Scholar publication record for Nimrat Chatterjee
  16. ↑ Semantic Scholar publication record for Nimrat Chatterjee
  17. ↑ Semantic Scholar publication record for Nimrat Chatterjee
  18. ↑ Semantic Scholar publication record for Nimrat Chatterjee
  19. ↑ Semantic Scholar publication record for Nimrat Chatterjee
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