Jump to content

Karen Glass

The neutral encyclopedia of notable people
Karen Glass
OccupationAcademic; biochemist
EmployerUniversity of Vermont
Known forResearch on histone modification recognition and bromodomain-containing proteins
EducationB.S., Microbiology, University of Massachusetts Amherst; Ph.D., Microbiology & Molecular Genetics, University of Vermont

Karen Glass is an associate professor of pharmacology at the University of Vermont. Her research focuses on the molecular mechanisms by which proteins recognize histone modifications, including work on bromodomain-containing proteins and epigenetic regulatory complexes.[1]

Education

Glass received a B.S. in Microbiology from the University of Massachusetts Amherst in 1999, mentored by Dr. Steven J. Sandler.[2] She earned a Ph.D. in Microbiology & Molecular Genetics from the University of Vermont in 2005, jointly mentored by Drs. Christopher S. Francklyn and Sylvie Doublie.[3] She subsequently completed the "Rapid Data Collection and Structure Solving at the NSLS" course at Brookhaven National Laboratory in 2003 and the NMRFAM Protein Structure Determination Workshop in 2010.[4]

Career

Glass began her research training as a Summer Undergraduate Research Student at the University of Vermont in 1998, in the Department of Microbiology and Molecular Genetics.[5] She completed a postdoctoral fellowship at the University of California, Santa Cruz from 2005 to 2006 under Harry F. Noller in the Department of Molecular, Cell and Developmental Biology, followed by a second postdoctoral fellowship at the University of Colorado Denver from 2006 to 2010 under Tatiana G. Kutateladze in the Department of Pharmacology.[6]

She joined the Albany College of Pharmacy and Health Sciences, Vermont Campus, as an Assistant Professor of Pharmaceutical Sciences in 2010, and was promoted to Associate Professor in 2016, a position she held until 2021.[7] Concurrently, she held adjunct appointments at the University of Vermont, serving as Adjunct Assistant Professor of Biochemistry from 2011 to 2019 and Adjunct Associate Professor of Biochemistry beginning in 2019.[8] In 2021, she joined the University of Vermont as an Associate Professor of Pharmacology.[9]

Research

Glass's published work, indexed by Semantic Scholar, comprises 50 papers with a combined total of 858 citations and an h-index of 13.[10] Her research addresses the structural and molecular basis of histone modification recognition, including studies on HBO1 acetyltransferase complexes, bromodomain proteins, and histone methylation marks.[11]

Her work has been supported by federal grant funding. The National Science Foundation awarded her a grant titled "MCA: Application of Cryo-Electron Microscopy to Determine the Structure of Epigenetic Regulatory Complexes" totaling $383,260, awarded to the University of Vermont & State Agricultural College on July 7, 2023.[12] She has also received National Institutes of Health funding across 12 projects totaling $3,089,806, including multiple awards for a project titled "Deciphering the molecular mechanisms of histone code recognition by ATAD2/B" at the University of Vermont & State Agricultural College, with individual awards of $10,140, $90,838, and $552,452.[13]

Selected publications

  • "Exchange of associated factors directs a switch in HBO1 acetyltransferase histone tail specificity" (2013), Genes & Development[14]
  • "Conserved Molecular Interactions within the HBO1 Acetyltransferase Complexes Regulate Cell Proliferation" (2011), Molecular and Cellular Biology[15]
  • "Histone H3R2 symmetric dimethylation and histone H3K4 trimethylation are tightly correlated in eukaryotic genomes" (2012), Cell Reports[16]
  • "Biological function and histone recognition of family IV bromodomain-containing proteins" (2017), Journal of Cellular Physiology[17]
  • "Molecular insights into the recognition of N-terminal histone modifications by the BRPF1 bromodomain" (2013), Journal of Molecular Biology[18]
  • "Molecular mechanism of MLL PHD3 and RNA recognition by the Cyp33 RRM domain" (2010), Journal of Molecular Biology[19]
  • "Structural insight into p53 recognition by the 53BP1 tandem Tudor domain" (2010), Journal of Molecular Biology[20]
  • "Functional Roles of Bromodomain Proteins in Cancer" (2021), Cancers[21]
  • "Curcumin and dimethoxycurcumin induced epigenetic changes in leukemia cells" (2014), Pharmaceutical Research[22]
  • "Mechanism of Histone H3K4me3 Recognition by the Plant Homeodomain of Inhibitor of Growth 3" (2016), Journal of Biological Chemistry[23]
  1. ↑ Semantic Scholar author profile, Karen Glass
  2. ↑ ORCID record 0000-0002-2761-733X
  3. ↑ ORCID record 0000-0002-2761-733X
  4. ↑ ORCID record 0000-0002-2761-733X
  5. ↑ ORCID record 0000-0002-2761-733X
  6. ↑ ORCID record 0000-0002-2761-733X
  7. ↑ ORCID record 0000-0002-2761-733X
  8. ↑ ORCID record 0000-0002-2761-733X
  9. ↑ ORCID record 0000-0002-2761-733X
  10. ↑ Semantic Scholar author profile, Karen Glass
  11. ↑ Semantic Scholar author profile, Karen Glass
  12. ↑ National Science Foundation award records
  13. ↑ National Institutes of Health award records
  14. ↑ Semantic Scholar author profile, Karen Glass
  15. ↑ Semantic Scholar author profile, Karen Glass
  16. ↑ Semantic Scholar author profile, Karen Glass
  17. ↑ Semantic Scholar author profile, Karen Glass
  18. ↑ Semantic Scholar author profile, Karen Glass
  19. ↑ Semantic Scholar author profile, Karen Glass
  20. ↑ Semantic Scholar author profile, Karen Glass
  21. ↑ Semantic Scholar author profile, Karen Glass
  22. ↑ Semantic Scholar author profile, Karen Glass
  23. ↑ Semantic Scholar author profile, Karen Glass
Retrieved from "https://biography.wiki/index.php?title=Karen_Glass&oldid=45337"