Jim Vigoreaux
| Jim Vigoreaux | |
| Occupation | Biologist, academic |
|---|---|
| Known for | Research on flightin and Drosophila flight muscle structure |
Jim Vigoreaux is a biologist and professor of biology at the University of Vermont, known for his research on the structure and function of insect flight muscle, particularly the myofibrillar protein flightin in Drosophila melanogaster.[1]
Career
Vigoreaux has served as a professor in the Department of Biology at the University of Vermont since 1991.[2]
Research
Vigoreaux's research has focused on the molecular components of Drosophila flight muscle, including his characterization of Z-band proteins and his identification and study of flightin, a myofibrillar protein found in stretch-activated muscles.[3] His work has examined flightin's role in thick filament assembly, sarcomere stability, and flight muscle mechanics, as well as the effects of phosphorylation on muscle power output and the impact of aging on flight muscle performance.[4][5][6]
According to Semantic Scholar, Vigoreaux has published 77 papers that have been cited a total of 2,168 times, giving him an h-index of 29.[7]
His research has been supported by multiple grants from the National Science Foundation totaling $3,282,302, including funding for studies on the structural role of flightin in thick filaments, the molecular phylogeny of flightin and the evolution of insect flight muscle, and the role of flightin phosphorylation in thick filament assembly and flight muscle mechanics.[8]
He has also received National Institutes of Health funding, including support through the American Society for Cell Biology for projects related to improving diversity and career transitions, totaling over $1 million across multiple awards.[9]
Selected publications
- "Characterization of components of Z-bands in the fibrillar flight muscle of Drosophila melanogaster" (1989), Journal of Cell Biology
- "Flightin, a novel myofibrillar protein of Drosophila stretch-activated muscles" (1993), Journal of Cell Biology
- "Flightin Is Essential for Thick Filament Assembly and Sarcomere Stability in Drosophila Flight Muscles" (2000), Journal of Cell Biology
- "Phosphorylation-dependent power output of transgenic flies: an integrated study" (1997), Biophysical Journal
- "Genetics of the Drosophila flight muscle myofibril: a window into the biology of complex systems" (2001), Bioessays
- "Aging enhances indirect flight muscle fiber performance yet decreases flight ability in Drosophila" (2008), Biophysical Journal
- "Drosophila has a twitchin/titin-related gene that appears to encode projectin" (1991), Proceedings of the National Academy of Sciences of the United States of America
- "Nature's versatile engine: insect flight muscle inside and out" (2005)
- "Suppression of muscle hypercontraction by mutations in the myosin heavy chain gene of Drosophila melanogaster" (2003), Genetics
- "Concentrations of Glycolytic Enzymes and Other Cytosolic Proteins in the Diffusible Fraction of a Vertebrate Muscle Proteome" (2005), Molecular & Cellular Proteomics
External links
- ↑ ORCID iD 0000-0002-3351-3801
- ↑ ORCID iD 0000-0002-3351-3801
- ↑ Vigoreaux et al., "Flightin, a novel myofibrillar protein of Drosophila stretch-activated muscles," Journal of Cell Biology, 1993.
- ↑ Vigoreaux et al., "Flightin Is Essential for Thick Filament Assembly and Sarcomere Stability in Drosophila Flight Muscles," Journal of Cell Biology, 2000.
- ↑ Vigoreaux et al., "Phosphorylation-dependent power output of transgenic flies: an integrated study," Biophysical Journal, 1997.
- ↑ Vigoreaux et al., "Aging enhances indirect flight muscle fiber performance yet decreases flight ability in Drosophila," Biophysical Journal, 2008.
- ↑ Semantic Scholar author profile for Jim Vigoreaux
- ↑ National Science Foundation award records, University of Vermont & State Agricultural College
- ↑ National Institutes of Health award records, American Society for Cell Biology