Brian Eckenroth
| Brian Eckenroth | |
| Occupation | Structural biologist |
|---|---|
| Education | B.S. Biochemistry (1996); Ph.D. Biochemistry (2007) |
| Alma mater | University of Maine; University of Vermont |
Brian Eckenroth is a structural biologist at the University of Vermont, where he serves as a Faculty Scientist in the Department of Microbiology and Molecular Genetics.[1] His research has addressed the structural biology of DNA damage recognition and repair, spore germination proteases, and thioredoxin reductase enzymes.[2][3]
Education
Eckenroth received a B.S. in Biochemistry from the University of Maine in 1996.[4] He earned a Ph.D. in Biochemistry from the University of Vermont, completing the degree between 2002 and 2007.[5]
Career
Prior to his graduate studies, Eckenroth worked at IDEXX Laboratories in the United States, first as a Production Specialist from 1996 to 1997, then as a Chemist I in Quality Control from 1997 to 1998, and subsequently as a research assistant and associate in Research and Development from 1998 to 2002.[6]
After completing his Ph.D., he undertook a postdoctoral fellowship in Biochemistry at the University of Vermont College of Medicine from 2007 to 2009.[7] He then worked as a Researcher/Analyst in the Department of Microbiology and Molecular Genetics at the University of Vermont from 2009 to 2019, before being appointed Faculty Scientist in the same department in 2019.[8]
Research
Eckenroth's published work spans structural and mechanistic studies of several enzyme systems. His research on the structure of human transferrin bound to the transferrin receptor, published in the Proceedings of the National Academy of Sciences of the United States of America in 2011, has been cited 147 times according to Semantic Scholar.[9] He has also contributed to structural and functional analyses of the CspB protease involved in Clostridium spore germination, published in PLoS Pathogens in 2013 and cited 118 times.[10]
Earlier in his career, Eckenroth conducted mechanistic studies of mammalian thioredoxin reductase, including semisynthesis and characterization work published in Biochemistry in 2006, cited 77 times, and further structural and biochemical investigations of the enzyme's catalytic mechanisms published in 2007 and 2008.[11] His 2010 study on tRNAHis guanylyltransferase, published in the Proceedings of the National Academy of Sciences of the United States of America, described unexpected structural homology between this nucleotidyl transferase and canonical DNA polymerases and has been cited 53 times.[12]
According to Semantic Scholar, Eckenroth has authored 60 papers that have collectively been cited 777 times, giving him an h-index of 15.[13]
His research on DNA damage recognition and repair in cancer has been supported by the National Institutes of Health through a series of grants to the University of Vermont totaling $1,069,577 across seven funded projects.[14]
Selected publications
- How the binding of human transferrin primes the transferrin receptor potentiating iron release at endosomal pH (2011), Proceedings of the National Academy of Sciences of the United States of America[15]
- Structural and Functional Analysis of the CspB Protease Required for Clostridium Spore Germination (2013), PLoS Pathogens[16]
- Semisynthesis and characterization of mammalian thioredoxin reductase (2006), Biochemistry[17]
- tRNAHis guanylyltransferase (THG1), a unique 3′-5′ nucleotidyl transferase, shares unexpected structural homology with canonical 5′-3′ DNA polymerases (2010), Proceedings of the National Academy of Sciences of the United States of America[18]
- The CspC pseudoprotease regulates germination of Clostridioides difficile spores in response to multiple environmental signals (2018), bioRxiv[19]
- Selenium in Thioredoxin Reductase: A Mechanistic Perspective (2008), Biochemistry[20]
- Investigation of the C-terminal redox center of high-Mr thioredoxin reductase by protein engineering and semisynthesis (2007), Biochemistry[21]
- Structural and biochemical studies reveal differences in the catalytic mechanisms of mammalian and Drosophila melanogaster thioredoxin reductases (2007), Biochemistry[22]
- Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomain (2014), FEBS Letters[23]
- Unique Structural Features of Mammalian NEIL2 DNA Glycosylase Prime Its Activity for Diverse DNA Substrates and Environments (2020), bioRxiv[24]
External links
- ↑ ORCID record 0000-0003-4818-311X
- ↑ National Institutes of Health grant records
- ↑ Semantic Scholar author profile
- ↑ ORCID record 0000-0003-4818-311X
- ↑ ORCID record 0000-0003-4818-311X
- ↑ ORCID record 0000-0003-4818-311X
- ↑ ORCID record 0000-0003-4818-311X
- ↑ ORCID record 0000-0003-4818-311X
- ↑ Semantic Scholar author profile
- ↑ Semantic Scholar author profile
- ↑ Semantic Scholar author profile
- ↑ Semantic Scholar author profile
- ↑ Semantic Scholar author profile
- ↑ National Institutes of Health grant records
- ↑ Semantic Scholar author profile
- ↑ Semantic Scholar author profile
- ↑ Semantic Scholar author profile
- ↑ Semantic Scholar author profile
- ↑ Semantic Scholar author profile
- ↑ Semantic Scholar author profile
- ↑ Semantic Scholar author profile
- ↑ Semantic Scholar author profile
- ↑ Semantic Scholar author profile
- ↑ Semantic Scholar author profile